By Natasha Wadlington, PhD.

Dr. Virginie Buggia-Prévot is a research scientist at the Institute for Applied Cancer Science at The University of Texas MD Anderson Cancer Center. She serves as head of neuroscience target discovery and validation at the Neurodegeneration Consortium, a collaboration of MD Anderson, Baylor College of Medicine and the Massachusetts Institute of Technology (MIT). Her role is to act as a liaison between consortium members at MD Anderson and top scientists in the field at MIT and Baylor College of Medicine to find new targets for therapies to stop, slow or reverse Alzheimer’s disease. Her work involves interacting with many of the researchers and postdocs as well as keep up with the changing trends in literature. Virginie finds the experience both enriching and fun.

To arrive at her current position in Houston, Texas, Virginie faced many trials and tribulations. Through perseverance and a great support network, she gained many experiences, accumulated great wisdom and succeeded at finding a career about which she is passionate.

Virginie was born in Grenoble, France. In France, she discovered her love for the sciences and as an undergraduate, working in a lab that focused on Parkinson’s disease. Continuing her focus on neurodegenerative diseases, she completed her Ph.D. at Le Centre National de la Recherche Scientifique in Nice Sophia-Antipolis, France. There she studied amyloid-beta and found a novel pathway in which it associated with neuroinflammation in Alzheimer’s disease. It was at this point Virginie decided to take a chance, leave France and pursue Alzheimer’s disease as a postdoc at the University of Chicago. While transitioning from France to the United States was a challenge, she found that the transition from postdoc to her current position more demanding.

At this point of her life, Virginie knew she had a crucial decision to make.

“At the same time you have to try to find opportunities,” she says.

As a postdoc, Virginie published eight articles in peer-reviewed journals, including work on the transport of the Alzheimer’s disease-associated protein BACE1, obtained $180,000 in grant funding for her research and provided the critical data to help fund a project with collaborators at Northwestern University for $400,000. However, obtaining data and becoming published were not the only keys to her success. She had to learn how to effectively network.

Virginie has learned that postdocs are not always aware of how to network efficiently, with many experiencing “failures and bad experiences.” To combat this issue, Virginie openly sought out sources to network and communicate. She became the co-chair for the seminar and social media committees at the University of Chicago’s Biological Science Division Postdoctoral Association. There were plenty of opportunities to interact with people within the university. She also enjoyed communicating outside the university through social media channels such as Twitter. Aside from gaining access to a community of academics and biotech groups outside of the University of Chicago, she also received followers from peer-reviewed journals and foundations.

“It’s always nice to be able to do something and also to promote the foundations,” says Virginie.

Meeting some of those followers in person was a great way to connect with others personally and professionally. So many postdocs do great work but their exposure may be limited, she says.

“It’s essential to have a good LinkedIn page and to promote your work. Everybody Googles you now,” says Virginie.

She fully used these tools and, as a result of the contacts she gained, successfully transitioned from postdoc to her position at MD Anderson.

Life is not meant to be all work and no play. MD Anderson encourages its employees to maintain a work-life balance. For Virginie, that notion can be a little difficult at times.

“I have a very hard time turning off my brain at night,” she says. “I’m the type of person who will wake up in the middle of the night and draw schematics and write down experiments.”

She has a true passion for science and recognizes that when you love what you do, it can be hard to walk away. Luckily for Virginie, she has found that balance with her husband, a non-scientist. They both value the arts and enjoy visiting museums and traveling in their spare time. She attributes her love for all things culinary to her French roots and takes joy in cooking at home. Virginie has found that great balance between working in an environment that she loves and living her life to the fullest extent.

For people trying to find their way through STEM careers, she offers some wise advice.

“If you are passionate about something, it will be transparent and people will definitely give you opportunities,” says Virginie. “Find people who inspire you and surround yourself with people who believe in you. Share your passions with the world and your friends because you never know where you are going to find your next opportunity. By verbalizing the things you like, the more it would be clear in your head what you are looking for.”

Virginie’s perseverance through adversity and challenges is inspiring to women in STEM everywhere.

By Rashika Rangaraj

Dr. Eileen Dolan, Professor of Medicine at the University of Chicago, is dedicated to transforming patient care and health through her research by combining laboratory discoveries with patient needs. Her motto has always been to improve the patient’s quality of life, which she has successfully pursued using different approaches that range from pharmacological modifications of a single protein to identifying gene variants, with the ultimate goal of making chemotherapy more efficient and less toxic. In addition to training several scientists and inspiring many more, many of whom are independent scientists, she has also initiated two programs that introduce cancer research to enthusiastic high schoolers to help them gain a better understanding of current developments in research and inspire them to pursue a career in research.

Dr. Dolan, by training, is a chemist, having completed her bachelors at the University of Dayton and her doctoral degree in Medicinal Chemistry from Purdue University. With her strong background in analytical chemistry, she transitioned into drug development and obtained her training in biochemical pharmacology in Dr. Anthony Peggs’ lab at Pennsylvania State University. During her postdoctoral study she focused on developing compounds to inhibit a specific DNA repair protein that would later passage into clinical trials against cancer. Following this she obtained her first position at the University of Chicago as a translational oncologist. Through her newly founded lab in the department of Medicine, she applied her strong chemistry and pharmacology background to address clinically relevant questions to meet the needs of cancer patients.

Then came one of the biggest turning points of her career, where she made a dramatic switch to venture into what was then an exciting, emerging field, now continues to be one with lots of promise- Pharmacogenomics. This field combines the powers of genomics and pharmacology to identify genetic variations that affect drug response and drug toxicity. She strongly believes this would eventually lead to evaluating patients for genetic variants upon which their course of therapy could be decided such that effective outcomes with lowered toxicity could be achieved, also popularly termed as “personalized medicine”. It promises to greatly improve lives of several patients suffering from toxic side-effects of chemotherapy like hearing loss and neuropathy. She has pioneered in developing novel cell-based models to study why different patients respond differently to the same chemotherapy regiment. She notes that the answer lies in their genetic make-up. She placed emphasis on taking an unbiased approach to research by “stepping back and allowing the data to dictate”. She notes that the field of genomics has been revolutionized by unbiased analysis of genomic data, where intronic (non-coding) regions in the DNA could also play a vital role in complex diseases such as cancer.

Improving patient lives is not the only gratifying part of her work; she also enjoys being an educator and mentor. Besides mentoring many graduate students, medical students and post-docs, she has initiated two notable projects to inspire young minds to pursue science. The first is the Continuing Umbrella of Research Experience (CURE) program which is designed for the most promising high school and undergraduate students from underrepresented populations interested in pursuing careers in cancer research. This allows students to immerse themselves in hands-on research and complete small achievable projects under established mentors at the University of Chicago. The second program is called researcHStart, an 8-week cancer-focused research and career development experience for the most promising high school students from the Chicago and Champaign-Urbana areas.

Drawing from her own experiences, her one advice was, “ taking risks is a big part of succeeding in life”. She stressed that as a woman one needs to cultivate a courageous, willing to take risks type of personality at the same time remember that things will not always work out as planned and be open to failure.

Dr. Dolan is an avid runner, loves to perform yoga and enjoys cooking for her family. Additionally, she spends time over the weekends with elderly citizens. She notes that their unique perspective on life is enchanting.

by Katarina Kotnik Halavaty, PhD

Guylaine Haché is a technical advisor at Rakoczy Molino Mazzochi Siwik LLP, a litigation and intellectual property law firm in Chicago, IL. She is pursuing her J.D. (Juris Doctor) degree at the Chicago-Kent College of Law, Illinois Institute of Technology. Prior to starting her law career, Guylaine obtained her Ph.D. in molecular biology from the University of Minnesota Twin Cities.

“I love science. In fact, I consider myself a scientist first and a patent practitioner second.” For her doctoral thesis, Guylaine studied the molecular mechanism by which a family of proteins called APOBEC can mutate the HIV genome. Her work was recognized as an outstanding research by graduate students in the basic biomedical sciences, and she was awarded the Beatrice Z. Milne and Theodore Brandenburg Award. While in graduate school, she held doctoral studentships from the Natural Sciences and Engineering Research Council of Canada and Canadian Institutes of Health Research. After successfully completing her doctoral research Guylaine moved to Chicago to begin postdoctoral training at Northwestern University Feinberg School of Medicine. There, she studied the life cycle of HPV. In total, she authored six and co-authored three scientific articles in recognized peer reviewed journals during her short research career at the bench.

During her postdoctoral training, Guylaine began questioning whether laboratory research was the right career for her. She desired more scientific diversity rather than focusing on the narrow area of research in which she had specialized. It was a discussion with a postdoctoral colleague, Marta New, PhD, MBA, that led her to explore a career in patent law. At the time Marta was transitioning from her postdoctoral position to Entrepreneur in Residence at Northwestern University’s Innovation and New Ventures Office. “Marta brought technology transfer and patent law to my attention,” says Guylaine. After doing some research she realized that with her scientific background she would fit well in law firms specializing in patent law to protect clients’ inventions. “I was especially excited about the prospect of working at the cutting-edge of research and being exposed to a wide range of technologies,” she explains. After conducting a few informational interviews with patent attorneys, Guylaine decided to turn her research expertise and her desire to learn about a wide range of scientific issues into her new profession.

Guylaine left academia. “I was very motivated to make the switch to patent law, so I applied to numerous law firms across the country.” In the end, Guylaine landed a job as a technical advisor with Ropes & Gray LLP in Boston, MA. In her new position at Ropes & Gray, Guylaine assisted drafted and prosecuted patent applications for the firm’s clients in the United States and abroad. “Basically, this includes talking to clients about their potentially patentable inventions, conducting searches in various databases to identify what has already been invented and published, drafting and filing patent applications, and taking patent applications through the patent examination process.” While at Ropes & Gray, Guylaine prosecuted patents in a wide range of technologies including molecular biology, immunology, photodynamic therapy, medical devices and diagnostics. She says that one of the most satisfying aspects of patent law is that, “It offers the opportunity to work on a wide variety of topics where one can learn about cutting-edge research before it’s published.”

Guylaine has since left Boston and is now back in Chicago. She now works as a technical advisor for Rakoczy Molino Mazzochi Siwik LLP, a mid-sized litigation and intellectual property law firm devoted exclusively to the pharmaceutical industry. In her current position, Guylaine provides technical litigation support to attorneys, works with experts to develop theories for use in patent litigation, as well as assists with patent counseling and due diligence analyses. She emphasizes that paying attention to details and having good analytical as well as communication skills are critical in her profession. A small mistake can have a serious consequence for a client. “I did not have to think about how a mistake might impact a client while performing bench research in academia,” she admits. Another situation that she encounters in her non-academic role at times is, “It’s a service industry, and clients always come first.” Now these challenges are part of her every day work.

Guylaine is attending Chicago-Kent College of Law in the evening. She is on track to graduate law school in December 2016 and looks forward to taking on more responsibilities as an attorney with Rakoczy Molino Mazzochi Siwik. She is excited to have “a more active role on cases, including taking and defending depositions, participating in negotiations and mediations, and attending court hearings.” While Guylaine enjoys applying her scientific background in a legal and business setting, she finds working and going to law school quite challenging at times. “It’s not for everyone,” she says. She recalls that at one point, she was working 8-5, attending law school by night, and getting home to study until midnight, only to get up in the morning to do it all over again. Speaking from her experiences in pursuing her goals, she believes that hard work and perseverance are the secrets to success. In the process of achieving goals she advises the following: “Just work hard and good things will happen!”

by Karen Chien, PhD.

Dr. Joan Cook-Mills, PhD, is a Professor in the Division of Allergy-Immunology at Feinberg School of Medicine, Northwestern University.

Joan is a well established investigator who has published over 50 peer reviewed articles in journals including the Journal of Physiology-Lung and the Journal of Immunology. Her research interests range from leukocyte migration during inflammation and allergic disease to the signaling of vascular endothelial adhesion molecule (VCAM-1). One of her most important findings involves the regulation of lung function by vitamin E isoforms. She discovered that when humans consumed gamma-tocopherol, the form of vitamin E found in corn, soybean, and canola oils, there was an association with a higher incidence of asthma; the consumption of alpha tocopherol, the vitamin E isoform present in olive and sunflower oils, was associated with increased lung function. Her work uncovered mechanisms in which vitamin E can regulate the immune system. This work of paramount importance in understanding the health benefits of vitamin E has been featured internationally in media and magazines including MORE Magazine, Medical Daily, and the New York Times.

Joan spent her childhood in the small town of Charlevoix in northern Michigan, where there were only two stoplights when she was growing up! She has always had an interest in science and medicine. Although she majored in pre-medicine during college, she found that she wanted to pursue research after talking to professionals in different areas. She became intrigued with immunology after a recruitment summer internship in an immunology focused lab within the biochemistry department at Michigan State University. After receiving her PhD, she completed postdoctoral research in the field of neuro-immunology at the University of Illinois at Chicago. She then spent 13 years as faculty at the University of Cincinnati, where she enjoyed working with and being surrounded by immunologists, before coming to Northwestern.

Joan chose the academic track because of a good personality fit and interest level in science. But most importantly, she enjoys being able to dive deep into the interesting questions while exploring scientific literature. Ultimately, she hopes that her work can unravel biological mechanisms of the human body that can be used to help people live better and healthier lives. Her background allows her to be creative and to study the interface between immunology, vascular biology/cardiology, neurology, signaling, and nutrition.

The motivation and drive that Joan brings to the lab is inspiring to her students and mentees. Joan has mentored many students as part of the Summer Research Opportunities Program with a focus on minorities as well as trained many women of all ages. Her dedication to research is shown by her commitment to constantly working directly at the bench alongside her students. The reason why she remains active in the lab is that “doing the experiments helps to troubleshoot with students”. Her greatest satisfaction as a mentor and professor comes from seeing a student reach the “Eureka!” moment in understanding a scientific concept. She highly encourages women to seek resources and training through different programs. This exposure gives opportunities to talk to others to find out what one is good at and passionate about; both men and women mentors can have very complementing but unique perspectives which can be helpful. Also, she emphasizes that networking and maintaining a network is important for growth and success in science. Her main advice to young scientists is, “Do whatever you really like doing because you’re going to be doing it a lot”. Being passionate about your interests in your life is critical, and also “Never give up. Don’t ever be afraid. Just go for it!”